Clinicopathologic features of anaplastic large cell lymphoma in children
- Author:
Qing SHI
1
Author Information
1. Department of Pathology
- Publication Type:Journal Article
- Keywords:
Child;
Immunohistochemistry;
Lymphoma, large-cell
- From:
Tumor
2007;27(9):747-749
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the clinical manifestations and histopathological and immunohistochemical features of anaplastic large cell lymphoma (ALCL) in children. Methods: We analyzed the clinical data, performed pathological examination, and tested the immunophenotypes of four ALCL children who were admitted in our hospital from 2001 to 2006. Results: The main clinical manifestations included enlarged superficial lymphnodes, rapid development disease, irregular fever, and hepatosplenomegaly. Morphological examination showed that the normal structure of lymphnode was destroyed and the large cells infiltrated into lymphnode sinuses. The tumor cells had large size with eccentric, horseshoe or kidney-shaped nucleus. Immunohistochemical analysis showed that the tumor cells positively expressed activin receptor-like kinase-1 (ALK-1), epithelial membrane antigen (EMA), and Ki-1. Conclusion: Detection of the expression of ALK-1, Ki-1, and EMA in ALCLs will provide assistance for diagnosis and differential diagnosis of ALCLs.
