The relationship between the serum levels of vascular endothelial growth factor (VEGF) basic fibroblast growth factor (bFGF) as well as the biological behaviors of gastric cancer
- Author:
Hong-Feng ZHOU
1
Author Information
1. Department of Internal Medicine
- Publication Type:Journal Article
- Keywords:
Fibroblast growth factor 2;
Serologic tests;
Stomach neoplasms;
Vascular endothelial growth factors
- From:
Tumor
2007;27(9):733-736
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To discuss the relationship between vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) and the biological behaviors of gastric cancer and, the relationship between the serum levels of VEGF, bFGF and the chemotherapeutic efficacy in patients with recurrent and metastatic gastric cancer. Methods: The serum levels of VEGF and bFGF were detected by ABC-ELISA method. Results: (1) The serum levels of VEGF and bFGF were significantly higher in preoperative stomach cancer patients than those in the healthy controls (P < 0.05) and postoperative stomach cancer patients (P < 0.05). (2) The serum levels of VEGF and bFGF significantly correlated with the depth of invasion, TNM staging, lymph node metastasis, and distant metastasis of primary cancer. (3) The serum level of VEGF had positive correlation with the serum level of bFGF in gastric cancer patients before radiochemotherapy (r =0.439, P <0.01). (4) The levels of VEGF and bFGF are significantly higher in preoperative patients with recurrent and metastatic gastric cancer than that in healthy controls and disease-free survival subjects (P < 0.05). After chemotherapy the serum levels of VEGF and bFGF in patients with no change (NC) or in progressive disease (PD) were a little higher than that before chemotherapy but the difference was not significant (P >0.05). (5) The serum levels of VEGF and bFGF were significantly lower in patients with complete response (CR) + partial response (PR) than that with NC + PD group after recurrent and metastatic patients received chemotherapy (P < 0.05). Conclusion: The serum levels of VEGF and bFGF were related with biological behaviors and chemotherapeutic efficacy of gastric cancer. The serum levels of VEGF and bFGF may provide new markers for preoperative diagnosis, postoperative follow-up, monitoring of the metastasis or recurrence of gastric cancer.
