Expression of cyclooxygenase-2 in epithelial ovarian carcinoma and its significance
- Author:
Yang XIA
1
Author Information
1. Departement of Gynecologic Oncology
- Publication Type:Journal Article
- Keywords:
Cyclooxygenase 2;
Gene expression;
Ovarian neoplasms;
Prognosis;
Reverse transcriptase polymerase chain reaction
- From:
Tumor
2007;27(10):825-828
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the expression of cyclooxygenase-2 (COX-2) in epithelial ovarian carcinoma and its clinical significance. Methods: The expression of COX-2 mRNA was detected by RT-PCR in 32 cases of epithelial ovarian carcinoma, 10 cases of benign ovarian tumors and 10 cases of normal ovarian tissues. The correlation of COX-2 expression to the clinicopathological parameters and chemotherapy resistance were analyzed. Multivariate Cox analysis on prognostic factors was performed. Results: The expression of COX-2 mRNA (68.8%) in epithelial ovarian carcinoma was statistically higher than that in the benign ovarian tumors (0%) and the normal ovarian tissues(0%, P < 0.05). There was a significant correlation between COX-2 mRNA expression and lymphatic metastasis and the diameter of residual tumor (P < 0.05). But COX-2 mRNA transcription had no association with the clinical stages, histological grades, ascites occurrence (P > 0.05). The difference was significant in COX-2 mRNA transcription between the drug sensitive group and the chemoresistant group (P < 0.05). According to Multivariate Cox survival analysis, COX-2 expression, lymphatic metastasis, and the diameter of residual tumor were independent risk factors for predicting the prognosis of epithelial ovarian carcinoma (P < 0.05). Conclusion: COX-2 plays an important role in the oncogenesis, development, metastasis, and chemoresistance of epithelial ovarian carcinoma. The expression of COX-2 is an independent risk factor for predicting the prognosis of patients.
