Expressions of heparanase and CD44v6 in osteosarcoma tissues and their correlations
- Author:
Hong-Zhang GUO
1
Author Information
1. Institute of Orthopedics
- Publication Type:Journal Article
- Keywords:
Antigens, CD44;
CD44v6;
Gene expressions;
Heparanase;
Osteosarcoma
- From:
Tumor
2007;27(10):817-820
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the expression of heparanase and CD44v6 in osteosarcoma and analyze the correlation between them. Methods: The expressions of heparanase and CD44v6 in human osteosarcoma were detected by immunohistochemical staining. Results: The positive rates of heparanase and CD44v6 protein in osteosarcoma tissues were significantly higher in osteosarcoma tissues than in osteochondroma (79.6% vs 20.0% and 55.1% vs 25.0%, P < O. 05). Expressions of heparanase and CD44v6 had positive correlation (r=0.663, P < 0.001). Both of them were closely associated with clinical stage and metastasis of osteosarcoma. Conclusion: Overexpressions of heparanase and CD44v6 in human osteosarcoma may stimulate the adhesion, invasion, and metastasis of osteosarcoma.
