Effects of intraarterial perfusion of thermo-chemotherapy on the immune function of lymphocytes in patients with hepatocellular carcinoma
- Author:
Hui WANG
1
Author Information
1. Center of Interventional Treatment
- Publication Type:Journal Article
- Keywords:
Chemoembolization;
Immunity, cellular;
Interventional heated chemotherapy;
Liver neoplasms
- From:
Tumor
2007;27(11):920-922
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the changes in the immune function of T-lymphocyte subsets and natural killer (NK) cells after intraarterial perfusion of thermo-chemotherapy in patients with primary hepatic carcinoma and the clinical significance. Methods: The changes in the immune function of T-lymphocyte subsets and NK cells were examined by immunofluorescence staining in 84 cases of primary hepatic carcinoma before and after intraarterial perfusion of thermo-chemotherapy and compared with 78 cases who received conventional interventional chemotherapy (control group). Results: (1) There was no significant decrease in the proportion of CD3 + and CD4 + T- lymphocytes and the ratio of CD4+/CD8+ (P > 0.05), but the number of NK cells significantly increased (P < 0.05) after thermo-chemotherapy. The proportion of CD3 + and CD4 + T- lymphocytes and the ratio of CD4 +/CD8 + significantly declined after conventional interventional chemotherapy (P < 0.05). (2) There was no significant difference in the immune function of T-lymphocytes subsets and NK cells between the two groups before treatment (P > 0.05). At two weeks after treatment, the levels of CD3 + and CD4 + T- lymphocytes, the ratio of C04 +/CD8 +, and the number of NK cells in thermo-chemotherapy group were obviously higher than those in the control group (P < 0.05). Conclusion: Intraarterial perfusion of thermo-chemotherapy rapidly increases the number of T-lymphocytes and NK cells in the peripheral blood and effectively antagonizes the decrease in the immune function induced by conventional interventional chemotherapy, which plays a positive role in controlling tumor metastasis.
