Clinical observation on 125I seed brachytherapy combined with chemotherapy and thermotherapy for mid-advanced tumor
- Author:
Zhi-Yong ZHANG
1
Author Information
1. Department of Oncology
- Publication Type:Journal Article
- Keywords:
Brachytherapy;
Combined modality therapy;
Drug therapy;
Hyperthermia, induced;
Neoplasms
- From:
Tumor
2007;27(11):914-916
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the clinical value of brachytherapy with radioactive 125I seed implantation combined with chemotherapy and thermotherapy for mid-advanced tumor. Methods: Twenty two patients with mid-advanced tumor were implantated radioactive 125I seed followed by chemotherapy and thermotherapy. Their clinical data was retrospectively reviewed and analyzed. Total 445 125I seeds of (1.48-2.59) × 107 Bq were implanted into 26 foci with the guidance of surgery or CT. Combined chemotherapy and thermotherapy was performed after brachytherapy. All the patients were followed up. The blood biochemical index, immune function and biological parameters of oncology and imaging changes were measured. The short-term efficacy was evaluated. Results: The oncological parameters significantly decreased 3 months after operations. There were 5 patients with complete response (CR), 12 with partial response (PR), 2 with no change (NC), 3 with progressive disease (PD). The objective response rate was 77.3% (17/22). Local foci control rate was 95.5% (21/22). One patient had pneumothorax during 125I seed implantation and the other patient had seed migration in lung. No other severe complications were observed. Conclusion: Radioactive 125I seed implantation combined with chemotherapy and thermotherapy has good clinical effects in treating mid-advanced tumor with low occurrence of complications. It is a simple, safe, and effective method for combined treatment of mid-advanced tumor.
