Expression of Mcl-1 protein in human cervical lesions and its significance
- Author:
Yi HU
1
Author Information
1. Department of Obstetrics and Gynecology
- Publication Type:Journal Article
- Keywords:
Gene expression;
Immunohistochemistry;
Myeloid cell leukemia-1 gene;
Uterine cervical neoplasms
- From:
Tumor
2007;27(11):899-901
- CountryChina
- Language:Chinese
-
Abstract:
Objective. Myeloid cell leukemia-1 (Mcl-1) protein is one of the numbers in bel-2 superfamily, which plays an important role in controlling apoptosis, proliferation, and differentiation of tumor cells. This study was to detect the expression of Mcl-1 protein in different stages of human cervical lesions and to explore further their possible roles in the formation and progression of cervical cancer. Methods: The expression of Mcl-1 protein was detected in 83 paraffin-embedded specimens of the cervical tissues with immunohistochemical SP methods. Its clinical significance was analyzed associating with clinicopathological classification. Results: The positive rate of Mcl-1 protein expression was 4.0% 33.3%, and 74.2% in cervicitis, cervical intraepithelial neoplasia (CIN) and cervical cancer tissue, respectively. The difference was significant among the three groups (P < 0.05). The positive rate of Mcl-1 protein expression was significantly different between G1 + G2 and G3 cervical cancer (P < 0.05). The positive expression of Mcl-1 in cervical cancer had no association with CIN grade, FIGO stage, histological type, and lymph node metastasis (P > 0.05). Conclusion: Over-expression of Mcl-I may play an important role in the initiation and development of cervical cancer.
