Relationship between 14-3-3β expression of classic type of Kaposi's sarcoma in Xinjiang and its proliferation and apoptosis
- Author:
Yan ZENG
1
Author Information
1. Laboratory of Xinjiang Endemic and Ethnic Diseases
- Publication Type:Journal Article
- Keywords:
14-3-3 proteins;
Aapoptosis;
Cell proliferation;
Sarcoma, Kaposi
- From:
Tumor
2007;27(11):891-893
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the relationship between 14-3 -3β expression and proliferation and apoptosis of classic type of Kaposi's sarcoma (KS) in Xinjiang. Methods: Immunohistochemical Envision 2-step method was used to detect 14-3-3β expression in 10 cases of classic type of KS and 12 cases of normal skin tissues from healthy subjects. Cell proliferating index (PI) was measured. Cell apoptotic index (AI) was determined by the TdT-mediated dUTP nick end labeling (TUNEL) method. Results: The positive expression rate of 14-3-3β protein in KS tissues was significantly higher than that in normal skin tissues (P <0.001). The degree of positive reaction was significantly different between KS and normal skin tissues (t = 14.661, P <0.01). The PI and AI of KS cells were significantly higher than that of normal skin tissues(t = 5.427 and 2.712,P <0.05). The expression of 14-3-3β positively correlated with PI and AI (r = 0.770 and 0.879, P < 0.01). Conclusion: Over-expression of 14-3-3β is related with the loss of control of proliferation of classic type of Kaposi's sarcoma in Xinjiang. The apoptosis of KS is related with multiple pathways and regulates by several negative regulating factors.
