Correlation of TFPI-2 gene expression with invasion, metastasis, and prognosis of supraglottic carcinoma
- Author:
Ya-Nan SUN
1
Author Information
1. Department of Otorhinolaryngology-Head and Neck Surgery
- Publication Type:Journal Article
- Keywords:
Gene expression;
Laryngeal neoplasms;
Neoplasm metastasis;
Prognosis;
Tissue factor pathway inhibitor 2
- From:
Tumor
2008;28(1):40-43
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the relationship between TFPI-2 gene expression and the invasion, metastasis, and prognosis of supraglottic carcinoma. Methods: Reverse transcriptase polymerase chain reaction and immunohistochemical methods were used to examine the expression of TFPI-2 in supraglottic carcinoma, and the relationship between TFPI-2 expression and the clinicopathological features of supraglottic carcinoma were analyzed. Results: Positive ratio of TFPI-2 expression was significantly increased at protein and mRNA levels in supraglottic carcinoma tissues (P < 0.05). TFPI-2 mRNA and protein expression were decreased with the increase in the invasive depth of supraglottic carcinoma (P < 0.05). TFPI-2 mRNA and protein expression were significantly lower in supraglottic carcinoma tissues with nodal metastasis and at III-IV clinical stage than those without nodal metastasis and at I - II clinical stage (P < 0.05). The staining intensity of TFPI-2 protein was also decreased with increase in invasive depth and nodal metastasis (P < 0.05). The supraglottic carcinoma patients with negative TFPI-2 protein expression had poor prognosis than those with positive TFPI-2 expression. Conclusion: The downregulation of TFPI-2 has a close relationship with invasion and metastasis of supraglottic carcinoma, and it may serve as a helpful marker in evaluating the metastasis and prognosis of supraglottic carcinoma.