Analysis of long-term outcome of patients with acute promyelocytic leukemia treated with different regimens after complete remission
- Author:
Ming GUO
1
Author Information
1. Department of Hematology
- Publication Type:Journal Article
- Keywords:
Leukemia, promyelocytic, acute;
Postremission therapy;
Prognosis
- From:
Tumor
2008;28(2):150-152
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore a more effective treatment regimen for patients with acute promyelocytic leukemia (APL) after complete remission (CR). Methods: Fifty patients with newly diagnosed APL were induced to CR by all-trans retinoic acid (ATRA). They were divided into two groups. Twenty-three patients in group A were given with alternative therapy with compound realgar and natural indigo tablet (CRNIT) and combined chemotherapy. Twenty-seven patients in group B were treated with alternative therapy with ATRA and combined chemotherapy. Long-term clinical outcomes were compared between the two groups. Results: Eight of the total 50 patients relapsed. The relapse rates in group A and group B were 4.3% and 25.9%, respectively. The difference was significant (P = 0.038). The three-year and five-year disease-free survival (DFS) rate of group A was markedly superior than group B (100% and 91% vs 79% and 58%; P = 0.023). Conclusion: Alternative therapy with CRNIT and combined chemotherapy for APL patients after CR was more effective than that of ATRA and combined chemotherapy.
