Expressions of CD 44V6 and β-catenin in osteosarcoma and their clinical significance
- Author:
Cheng-Cun LI
1
Author Information
1. Department of Orthopaedic
- Publication Type:Journal Article
- Keywords:
Antigens;
Beta catenin;
CD 44;
Gene expression;
Neoplasm invasiveness;
Neoplasm metastasis;
Osteosarcoma
- From:
Tumor
2008;28(2):136-138
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To detect the expressions of CD 44V6 and β-catenin in osteosarcoma and to analyze the association of their expressions with migration and invasion of osteosarcoma cells. Methods: Expressions of CD 44V6 and β-catenin were examined by immunohistochemical SP method in 35 specimens of human osteosarcoma tissues, 15 specimens with osteochondroma, and 15 cases of normal bone tissues. Results: The positive expressions of CD 44V6 and β-catenin were significantly higher in osteosarcoma than osteochondroma and normal control tissues (P < 0.01). Their expressions significantly correlated with clinical staging, tumor metastasis, and 2-year death (P < 0.05); but had no correlation with the age and gender of patients, tumor size, histological classification, and with or without preoperative chemotherapy (P > 0.05). In osteosarcoma, expression of CD 44V6 was positively associated with the expression of β-catenin (P < 0.01). Conclusion: The positive expressions of CD 44V6 and β-catenin closely correlate with the occurrence, development, and metastasis of osteosarcoma. They may play synergistic role in the invasion and metastasis of osteosarcoma. Combined detection of CD 44V6 and β-catenin may be used as an indicater for diagnosis and prognosis of metastasis of osteosarcoma.
