The expressions of hypoxia-inducible factor-1α and cell adhesion molecules in pancreatic adenocarcinoma and their clinical significance
10.3781/j.issn.1000-7431.2008.03.019
- Author:
Zhen GAO
1
Author Information
1. Department of General Surgery
- Publication Type:Journal Article
- Keywords:
Antigens, CD 29;
E-cadherin;
Hypoxia-inducible factor-I, alpha subunit;
Immunohistochemistry;
Pancreatic neoplasms
- From:
Tumor
2008;28(3):256-259
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the relationship between the expressions of hypoxia inducible factor-1α (HIF-1α) and cellular adhesion molecules in human pancreatic adenocarcinoma, and discuss the mechanism for the promoting effects of HIF-1α on cancer invasiveness and metastasis and the clinical significance. Methods: Expressions of HIF-1α, E-cadherin and integrin β1 were detected by immunohistochemistry in 34 cases of radically resected pancreatic cancer tissues and 10 normal pancreatic tissues. The association of the expression of HIF-1α with the expression of E-cadherin and integrin β1 and the relationship between expression of HIF-1α and clinical features were analyzed. Results: There were overexpressions of HIF-1α, abnormal expression of E-cadherin, and high expression of integrin in pancreatic cancer tissues. Expression of HIF-1α negatively correlated with E-cadherin but had no significant relationship with expression of integrin. Expression of HIF-1α correlated with pathological staging and lymph node metastasis. Abnormal expression of E-cadherin was associated with tumor differentiation, pathological staging, and lymph node metastasis. Expression of integrin had no correlation with clinical features. Conclusion: HIF-1α promotes cancer invasiveness and metastasis by regulating abnormal expression of E-cadherin. Immunhistochemistry results indicated that detection of HIF-1α and E-cadherin may be valuable for judging the potential malignancy of pancreatic cancer.
