Expressions of PI3K/AKT/p-AKT in cervical intraepithelial neoplasia and cervical carcinoma and their relationship with Ki67
10.3781/j.issn.1000-7431.2008.04.011
- Author:
Shu-Jie LIAO
1
Author Information
1. Department of Gynecologic Oncology
- Publication Type:Journal Article
- Keywords:
Cervical intraepithelial neoplasia;
Immunohistochemistry;
Uterine cervical neoplasms
- From:
Tumor
2008;28(4):317-321
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To detect the expressions of PI3K, AKT, p-AKT, and Ki67 in cervical intraepithelial neoplasia (CIN) and cervical carcinoma and explore their relation with the occurrence and development of cervical diseases and the clinical significance. Methods: The expression of PI3K, AKT, p-AKT, and Ki67 in cervical intraepithelial neoplasia (CIN) and cervical carcinoma were detected by immunohistochemical SP methods. Results: (1) The expressions of PI3K, AKT, p-AKT, and Ki67 protein were significantly higher in cervical carcinoma than CIN and normal cervical tissues. The difference was significant (P <0.05). There was no significant difference between adenocarcima and squamous adenocarcinoma. CIN tissues had higher expressions of PI3K, AKT, p-AKT, and Ki67 proteins than normal control (P <0.05) and the difference was increased with the elevated grade of CIN. (2) The expressions of PI3K, AKT, and p-AKT correlated with Ki67 in CIN tissues at various grades. (3) The expressions of PI3K and p-AKT had correlation with histological differentiation and clinical stage, but not with age, histological subtype, lymph node metastases. Expression of Ki67 was not associated with clinicopathological parameters. Conclusion: The aberrant expressions of PI3K, AKT, p-AKT, and Ki67 were involved in the occurrence and development of cervical cancer and related with the enhanced proliferation of tumor cells.
