Multi-variate analysis of the prognostic factors for early stage Hodkin's lymphoma
10.3781/j.issn.1000-7431.2008.06.013
- Author:
Wen-Yong TAN
1
Author Information
1. Department of Radiotherapy
- Publication Type:Journal Article
- Keywords:
Antineoplastic combined chemotherapy protocols;
Hodgkin disease;
Prognosis;
Radiotherapy
- From:
Tumor
2008;28(6):510-513
- CountryChina
- Language:Chinese
-
Abstract:
Objective: There is controversy about the prognostic factors for early stage Hodgkin's lymphoma (HL). The aim of this study is to investigate the prognostic factors for HL at early stage. Methods: The clinical data from 188 patients were analyzed retrospectively. One hundred patients (53.2%) received radiotherapy (RT) alone and 88 cases (46.8%) received combined chemotherapy and radiotherapy. The 5-year and 10-year overall survival (OS) and disease-free survival (DFS) rates were estimated by Kaplan-Meier survival analysis with log-rank test. The prognostic factors were determined by COX proportional hazards model. Results: The 5-year and 10-year OS rates were 84.5% and 76.3% for patients who received radiotherapy alone, respectively; they were 96.2% and 96.2% for those patients who received combined chemotherapy and radiotherapy, respectively (P = 0.340). The 5-year and 10-year DFS rates were 84.7% and 76.9% for patients who received radiotherapy alone, respectively; they were 93.4% and 71.8% for patients who received combined therapy, respectively (P = 0.015). Univariate analysis indicated that tumor size and patients' age (with the cut-off of 40 years old) were the prognostic factors for predicting OS (P = 0.002 and 0.001) and DFS rate (P = 0.033 and 0.019). The pathological type had marginal significance in predicting OS rate (P = 0.072) and B symptoms had marginal significance in predicting DFS rate (P = 0.072). Multivariate analysis indicated that five factors including age (P =0.022), gender (P = 0.036), tumor size (P = 0.024), the drainage areas of involved lymph nodes (with the cut-off of 3 areas) (P = 0.060), and clinical stage (P = 0.028) had significance or marginal significance for predicting HL. Conclusion: Being more than 40 years old, male, clinical stage II, bulky disease, and the number of involved mediastinum and lymph node regions ≥3 are the independent prognostic factors for patients with early HL.
