The expressions of nm-23 and CD44v6 protein in non-small cell lung cancer and their clinical significance
10.3781/j.issn.1000-7431.2008.07.015
- Author:
Patiguli AERXIDING
1
Author Information
1. First Department of Medical Onology
- Publication Type:Journal Article
- Keywords:
Antigens;
Carcinoma, non-small cell lung;
CD44;
Gene expression;
Gene, nm23
- From:
Tumor
2008;28(7):609-612
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the expressions of nm23 and CD44v6 proteins in non-small cell lung cancer (NSCLC) and their clinical significance. Methods: Expressions of nm23 and CD44v6 proteins were detected in 58 cases with NSCLC by two-step immunohistochemistry. Results: The overall positive rate of nm23 staining was 87.9% (51/58). There was a significant difference between T1-T2 group and T3-T4 group (P < 0.05). The overall positive rate of CD44v6 was 55.2% (32/58). It was significantly higher in squamous cell carcinoma than that in adenocarcinoma (85.7% vs 24%, P < 0.05) and significantly higher in moderate differentiated group than that in poor- and well-differentiated group (71.9% vs 44.4% and 35.3%, P < 0.05). The expressions of nm23 and CD44v6 were not associated with pTNM stage, lymph node metastasis, and survival rate (P > 0.05). Conclusion: The expressions of nm23 and CD44v6 correlated with the tumor size, pathological classification, differentiation degree of NSCLC but had no relation with pTNM stage and lymphnode metastasis.
