Effect of anemia on prognosis of non-small cell lung cancer patients
10.3781/j.issn.1000-7431.2008.07.014
- Author:
Lin-Ping GU
1
Author Information
1. Shanghai Lung Tumor Clinical Medical Center
- Publication Type:Journal Article
- Keywords:
Anemia;
Carcinoma, non-small cell lung;
Prognosis
- From:
Tumor
2008;28(7):605-608
- CountryChina
- Language:Chinese
-
Abstract:
Objectives: To investigate the correlation of the hemoglobin levels with prognosis of non-small cell lung cancer (NSCLC) patients. Methods: The clinical data from 500 patients with NSCLC who were admitted in the Shanghai Chest Hospital from November 2003 to March 2005 were retrospectively analyzed. Statistical difference was analyzed by χ2 test. Survival analysis was evaluated by Kaplan-Meier and log-rank test. Multivariate analysis was performed by COX stepwise regression model. The hemoglobin levels were obtained at the initial visit to the hospital. Anemia is defined as a hemoglobin level <120 g/ L in men and <110 g/L in women. Results: The median survival time for all the 500 patients was 27.17 months, 1-year survival rate was 73.4%. Among them, 147 (29.4%) patients had anemia and 353(70.6%) patients without anemia. The incidence of anemia was higher in those patients who received chemotherapy. After the four-cycle chemotherapy, the proportion of patients experiencing anemia was 84.3%. The median survival time was 21.38 months for the patients with anemia and 30.82 months for patients without anemia. The 1-year survival rate was significantly lower in patients with anemia than those without anemia (64.3% vs 76.8%, P = 0.028). Anemia had significant influence on the survival time of female patients (P = 0.049). There was significant difference in the survival time between III stage patients with and without anemia (P = 0.035). Anemia had no significant effect on the survival of NSCLC patients at stages I, II, and IV. The COX stepwise regression analysis showed that anemia, sex, pathological classification, clinical stage, liver function, and surgical resection were independent prognostic factors for the NSCLC patients. Conclusion: Anemia determined by primary diagnosis was related with the survival time of NSCLC patients. Anemia is an independent prognostic factor for NSCLC patients.
