Chronic myeloid leukemia developed in the course of small lymphocytic lymphoma therapy and related literature review
10.3781/j.issn.1000-7431.2008.08.019
- Author:
Hua ZHONG
1
Author Information
1. Department of Hematology
- Publication Type:Journal Article
- Keywords:
Diagnostic tests, routine;
Leukemia, myeloid, chronic;
Lymphoma, small lymphocytic
- From:
Tumor
2008;28(8):712-715
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To clarify the relationship between the two malignancy diseases: small lymphocytic lymphoma/chronic lymphocytic leukemia (SLL/ CLL) and chronic myelogenous leukemia (CML) in the same patient. Methods: We performed bone marrow smear, lymph node biopsy, the cytogenetic and genome research, fluorescence in situ hybridization (FISH), and flow cytometry (FCM) in a 52-year-old male patient who developed Ph-positive CML 5 years after the onset of SLL/CLL and reviewed the related literature. Results: Bone marrow smear and the lymph node biopsy confirmed the SLL/ CLL diagnosis and FISH detection showed no Philadelphia (Ph)-positive chromosome in the early stage of disease. After 5-year chemotherapy, bone marrow culture demonstrated an abnormal karyotypes of 46, XY, t (9;22) (q34; q11). The bone marrow of the patient displayed typical features of CML. FCM detection confirmed that two abnormal clones coexisted in the same patient. Conclusion: These results indicate that the two neoplastic populations originated independently, the second neoplasia may be related with the over-therapy of the first neoplasia.
