A correlation study on magnetic resonance imaging features and nuclear DNA contents in meningiomas
10.3781/j.issn.1000-7431.2008.08.014
- Author:
Hong-Yan WANG
1
Author Information
1. Department of Radiology
- Publication Type:Journal Article
- Keywords:
Aneuploidy;
DNA, neoplasm;
Magnetic resonance spectroscopy;
Meningioma
- From:
Tumor
2008;28(8):694-698
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the correlation of magnetic resonance imaging (MRI) features with the tumor nuclear DNA contents, and evaluate the biological behavior and proliferative potential of meningiomas using MRI. Methods: The DNA contents and the incidence of aneuploid of 45 patients with meningiomas were measured by means of photodensity method with image cytometry. The data were compared with MR findings for the statistical correlation analysis. Results: Tumors with the presence of peritumoral edema, irregular tumor shape, and ambiguous brain-tumor border had remarkable difference in DNA contents compared with those with negative peritumoral edema, smooth tumor shape, and clear brain-tumor border (P < 0.01). Using Spearman' s correlation coefficient analysis, we found a significant correlation (r = 0.696, P = 0.000) between three of MRI scores calculated for each patient and DNA contents. Conclusion: DNA contents and the incidence of aneuploid are higher in the tumors with the presence of peritumoral edema, irregular tumor shape, and ambiguous brain-tumor border. All of the imaging appearances can be used to estimate the proliferation potency and malignant biological behavior of the meningiomas.
