The relationship between urinary isoflavone levels and the risk of endometrial cancer
10.3781/j.issn.1000-7431.2008.09.016
- Author:
Jing GAO
1
Author Information
1. Department of Epidemiology
- Publication Type:Journal Article
- Keywords:
Case-control studies;
Chromatography, high performance liquid;
Endometrial neoplasms;
Isoflavones
- From:
Tumor
2008;28(9):786-790
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the relationship between urinary excretion of isoflavones and the risk of endometrial cancer. Methods: Case-control study was used. Overnight urine samples were collected from 200 endometrial cancer cases and 200 controls. HPLC analysis was applied to quantify the urinary levels of daidzein, genistein, glycitein and equol. Non-conditional logistic regression was used to analyze the association of urinary level of the four isoflavones with the risk of endometrial cancer. Results: The urinary genistein level was substantially higher in endometrial cancer cases compared with controls. The median (25%, 75%) levels was 4.72 (1.19, 10.79) nmol/mg Cr for endometrial cancer patients and 2.43 (0.90, 9.16) nmol/mg Cr for controls (P <0.05). There was no significant difference in the urinary levels of other three isoflavones. No relationship was found between urinary isoflavones levels and the risk of endometrial cancer after adjusted for possible confounding factors such as age, menarcheal age, menstrual years, administration of oral contraceptive pills, BMI, and waist to hip ratio. Conclusion: No significant difference is found between urinary levels of isoflavones and risk of endometrial cancer.
