Multiple myeloma involved in central nervous system infiltration: A report of nine cases
10.3781/j.issn.1000-7431.2008.10.019
- Author:
Xiao-Mei WANG
1
Author Information
1. Department of Hematology
- Publication Type:Journal Article
- Keywords:
Central nervous system;
Multiple myeloma;
Prognosis
- From:
Tumor
2008;28(10):895-897
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the diagnosis, therapy, and prognosis of multiple myeloma (MM) involved in central nervous system infiltration. Methods: The clinical data on the diagnosis, therapy, and prognosis of 9 MM patients with central nervous system infiltration were analyzed retrospectively. Results: Nine out of 418 MM patients had central nervous system infiltration. The occurrence frequency was 2.2%. Meningeal infiltration was the most common complication (5/9) and pituitary infiltration was the second (2/9). All the patients had several extramedullary diseases in other soft tissues. The median follow-up interval was 30 months. The median overall survival (OS) time of the 9 patients was 29 months. After the central nervous system was infiltrated, the median OS time was only 5 months. Conclusion: Central nervous system infiltration occurrs rarely in MM. Meningeal infiltration is the most common complication and frequently accompanied with other soft tissue plasmacytoma. The prognosis is unfavourable for those patients with central nervous system plasmocytoma. There is no effective interferring method in clinic.
