AC or TA neoadjuvant chemotherapy may decrease the microvessel density but does not affect the expressions of P-gp and GST-π in breast carcinoma
10.3781/j.issn.1000-7431.2008.10.015
- Author:
Kun-Xian YANG
1
Author Information
1. Hospital of Yunnan Province
- Publication Type:Journal Article
- Keywords:
Adjuvant;
Breast neoplasms;
Chemotherapy;
Multidrug resistance associated proteins;
Neovascularization, pathologic
- From:
Tumor
2008;28(10):882-884
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the microvessel density and expression of multiple drug resistance (MDR) gene and their relationship in the same patient with breast carcinoma before and after neoadjuvant AC or TA chemotherapy. Methods: AC or TA regimen was selected to perform preoperative chemotherapy in 45 breast cancer patients. Immunohistochemisty (En vision method) was used to count the microvessel density (MVD) and determine the expressions of P-glycoprotein (P-gp) and glutathinine-S-transferase π (GST-π) of the same patients before and after neoadjuvant chemotherapy. Results: After neoadjuvant chemotherapy the MVD was decreased. The difference was significant (P < 0. 01). The expression levels of P-gp and GST-π partly changed but the difference was not significant (P > 0. 05). There was no significant correlation between MVD and the expressions of P-gp and GST-π (P > 0. 05) before and after neoadjuvant chemotherapy. The expression of P-gp had significant association with GST-π before and after neoadjuvant chemotherapy (P<0.01). Conclusions: AC or TA neoadjuvant chemotherapy decreases the number of microvessel density but does not affect the expressions of P-gp and GST-π in breast carcinoma. So this study suggests that AC or TA regimen could be considered first for neoadjuvant chemotherapy.
