Expressions of P-gp, ToPo II α, GST-π and c-erbB2 in endometrial cancer and their significance
10.3781/j.issn.1000-7431.2008.11.014
- Author:
Zhong-Min WANG
1
Author Information
1. Department of Gynecologic Oncology
- Publication Type:Journal Article
- Keywords:
Endometrial neoplasms;
Immunohistochemistry;
Multidrug resistance-associated proteins;
Prognosis
- From:
Tumor
2008;28(11):968-971
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the expressions of P-glycoprotein (P-gp), topoisomerase II alpha (ToPo II α), glutathione-S-transferase-pi (GST-π), and oncogene c-erbB2 in endometrial cancer and their significance. Methods: Immunohistochemistry SP method was used to determine the expressions of P-gp, ToPo II α, GST-π and c-erbB2 in 127 tumor samples from patients with endometrial cancer. Results: Among 127 tumor samples from patients with endometrial cancer, the positive expression rates of P-gp, ToPo II α, GST-π and c-erbB2 were 63.0%, 44.9%, 70.1%, and 47.2%, respectively. The co-expression rate of P-gp and GST-π was 50.7%. The expression levels of P-gp, GST-π and c-erbB2 in poor differentiation endometrial cancer were significantly higher than those in well/moderate differentiation endometrial cancer (P < 0.05). While the expression level of ToPo II α in well/moderate differentiation endometrial cancer was significantly higher than that in poor differentiation endometrial cancer (P < 0.05). Univariate analysis indicated that the expression of P-gp, GST-π and c-erbB2 were associated with the survival time and poor prognosis of endometrial cancer patients. COX regression analysis suggested that the expression of P-gp and co-expression of P-gp and GST-π correlated with the survival rate of patients. Over-expression of ToPo II α tended to have protective effects on patients. Conclusion: Multidrug resistance-associated protein (MRP), GST-π, Topo II α, and lung resistance protein (LRP) plays important roles in the multidrug resistance(MDR) of tumor chemotherapy. Combined effects of the four multiple factors, P-gp, ToPo II α, GST-π and c-erbB2 were the main action mechanism for the MDR of endometrial cancer. It has an important guiding significance for predicting the prognosis and making rational chemotherapeutic regimens for patients with endometrial cancer.
