Metronomic chemotherapy with UFT inhibits vasculogenic mimicry formations in human MKN-45 gastric cancer cells
10.3781/j.issn.1000-7431.2008.11.005
- Author:
Xin WU
1
Author Information
1. Department of Oncology
- Publication Type:Journal Article
- Keywords:
Drug therapy;
Neovascularization, pathology;
Stomach neoplasms;
Xenograft model antitumor assays
- From:
Tumor
2008;28(11):929-932
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To examine the effects of metronomic chemotherapy with UFT on vasculogenic mimicry(VM) formations in nude mice bearing MKN-45 gastric cancer cells and explore the possible mechanism. Methods: The tumor-bearing mouse model was established. UFT-based metronomic chemotherapy was performed. The efficacy and adverse reaction were observed. The number of VM was counted by HE and periodic acid Schiff (PAS) staining. The expression of CD31 was analyzed by immunohistochemistry. Results: MKN-45 tumor cells expressed CD3 endothelium-related molecules and formed PAS-positive vasculogenic mimicry. UVF-based metronomic chemotherapy markedly inhibited the formation of VM. But UFT at maximum using dosage had no inhibitory effects on VM formations. Conclusion: Metronomic UFT chemotherapy inhibits VM formations by MKN-45 gastric cancer cells.
