Clinical efficacy of CT-guided implantation of iodine 125 seeds combined with intra-arterial perfusion of gemcitabine plus 5-fluorouracil on pancreatic cancer
10.3781/j.issn.1000-7431.2008.012.020
- Author:
Zhong-Min WANG
1
Author Information
1. Department of Interventional Radiology
- Publication Type:Journal Article
- Keywords:
Brachytherapy;
Chemotherapy, cancer, regional perfusion;
Iodine radioisotopes;
Pancreatic neoplasms
- From:
Tumor
2008;28(12):1102-1105
- CountryChina
- Language:Chinese
-
Abstract:
Objectives: To evaluate the safety and efficacy of CT-guided iodine 125 seed implantation combined with gemcitabine and 5-fluorouracil (5-FU)-based intra-arterial perfusion in the treatment of patients with advanced pancreatic cancer. Methods: A total of 16 patients with advanced unresectable pancreatic cancer underwent CT-guided iodine implantation combined with gemcitabine plus 5-FU-based intra-arterial perfusion. One week after implantation of iodine 125 seeds, all the patients received concurrent intra-arterial infusion of gemcitabine and 5-FU, which was repeated for 3 to 4 cycles. Three patients complicated with liver metastasis were given additional arterial embolization concurrently. Survival period, pain-relieving period, and adverse reaction of patients were observed. Results: All the patients were followed up for 2-25 months. CT scan found that there were 2 cases with complete response, 9 cases with partial response, 3 cases with stable disease, and 2 cases with progressive disease after 2 months of follow-up. The overall effective rate (CR + PR) was 68.8%. The median survival period for all enrolled patients was 11 months. It was 15 months for patients at stage II + III and 9 months for those at stage IV. No serious complications including gastrointestinal bleeding, pancreatitis, pancreatic fistula and radiation colitis were observed. Conclusion: CT-guided iodine 125 seed implantation combined with gemcitabine and 5-fluorouracil (5-FU)-based intra-arterial perfusion has better palliative pain-relieving effects. It has safe and effective effects in short terms and causes less complications in the treatment of advanced pancreatic cancer patients.
