Relationship between magnetic susceptibility-weighted imaging and pathologic grading of brain gliomas
10.3781/j.issn.1000-7431.2008.12.014
- Author:
He HUANG
1
Author Information
1. Department of Radiology
- Publication Type:Journal Article
- Keywords:
Glioma;
Magnetic resonance imaging;
Pathology
- From:
Tumor
2008;28(12):1077-1080
- CountryChina
- Language:Chinese
-
Abstract:
Objectives: To estimate the value of magnetic susceptibility-weighted imaging (MSWI) in the pathologic grading of gliomas. Materials: Sixty patients with confirmed gliomas proved by pathological examination were prospectively examined. They were scanned by magnetic resonance (MR) turbo spin echo (TSE) T1-weighted imaging (WI) and dual fast low angle shot (FLASH)-T2* WI imaging with TE of 15 and 35 ms, respectively. The difference in the magnetic susceptibility artifact (MSA) induced by the various sequences was compared. The correlation of MSA [number, maximal diameter, and signal to noise ratio (SNR)] with WHO pathological grade and Ki-7 values were analyzed. Results: Multiplicity rank sum test and variance analysis indicated that there was a statistical difference in MSA between the three sequences, 15-ms FLASH-T2* WI, 35-ms FLASH-T2* WI, and TSE (χ 2 = 21.331, P = 0.001; F = 44.517 and 6.839,P <0.001). Pearson correlation analysis suggested that WHO pathological grade correlated with MSA parameters including number, maximal diameter and SNR (r =0.737, 0.624 and -0.528, P =0.000); the expression level of Ki-67 also correlated with MSA parameters including number, maximal diameter and SNR (r = 0.687, 0.577, and -0.533, P = 0.000). Conclusions: MSWI is helpful in the evaluation of preoperative pathologic grade of brain gliomas. MSA produced by longer TE FLASH (35 ms) is better than that produced by shorter TE FLASH (15 ms) to evaluate the pathologic grade of brain gliomas.
