Advances in the research of Hedgehog signaling pathway associated with the invasion and metastasis of tumors
10.3781/j.issn.1000-7431.2011.02.017
- Author:
Xiao-Bo OU-YANG
1
Author Information
1. Department of Gastroenterology
- Publication Type:Journal Article
- Keywords:
Hedgehog signaling system;
Neoplasm invasiveness;
Neoplasm metastasis;
Neoplasms;
Signal transduction
- From:
Tumor
2011;31(2):173-177
- CountryChina
- Language:Chinese
-
Abstract:
Hedgehog family proteins are important morphogens which mediate the development of embryo as well as the carcinogenesis in adults. Inappropriate activation of Hedgehog signaling pathway contributes to numerous human cancers. The Hedgehog signaling pathway is considered to be involved in the molecular mechanism of the invasion and metastasis of the tumors, and to facilitate the metastasis of tumors through signaling pathways interaction. It is suggested that a potential therapeutic strategy pharmacologically targeting Hedgehog-dependent tumors may be developed.
