Clinical research of low energy ultrasonic cavitation in treatment of solid tumors
10.3781/j.issn.1000-7431.2011.02.014
- Author:
Feng-Chun ZHANG
1
Author Information
1. Department of Oncology
- Publication Type:Journal Article
- From:
Tumor
2011;31(2):160-164
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the recent efficacy, long-term survival and the side effects of low energy ultrasonic cavitation in treatment of 53 patients with solid tumors. Methods: Fifty-three patients with solid tumors were randomly divided into three groups: group A (18 patients received low energy ultrasonic cavitation therapy combined with chemotherapy), group B (18 patients received chemotherapy alone) and group C (17 patients received low energy ultrasonic cavitation therapy alone). Low energy ultrasonic cavitation therapy was administrated five days in one week for 2 weeks or three times each week for 3 weeks. Results: All fifty-three patients were included in the analysis. In group A, one case achieved complete response (CR), 6 cases achieved partial response (PR) and 9 cases achieved stable disease (SD); the disease control rate (CR+PR+SD) was 88.61% (16/18). In group B, no cases achieved CR, 4 cases achieved PR and 7 cases achieved SD; the disease control rate was 61.11% (11/18). In group C, no cases achieved CR, 4 cases achieved PR and 6 cases achieved SD; the disease control rate was 58.82% (10/17). The difference of disease control rate between groups A and B was significant (P<0.05). One-year survival rates of these three groups were 66.67%, 44.44% and 41.18%, respectively, and two-year survival rates were 38.89%, 16.67% and 17.65%, respectively. The one- and two-year survival rates in group A were both higher than those in group B and group C (P<0.05), but the difference was not observed between group B and group C. The proportions of patients with improved quality of life in groups A, B and C were 83.33%, 55.56% and 58.82%, respectively. There was no blood toxicity in group C. The major toxicities were local pain and fever, which could be self-relieved. Conclusion: Low energy ultrasonic cavitation therapy in treatment of solid tumors is efficient and well-tolerated, and the quality.
