Polymorphism of exon G435T in RASSF 1A gene associated with the susceptibility of breast cancer
10.3781/j.issn.1000-7431.2011.03.014
- Author:
Jian-Guo LI
1
Author Information
1. Department of Breast Surgery
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Gene;
Gene frequency;
Polymorphism;
RASSF 1A;
Single nucleotide
- From:
Tumor
2011;31(3):261-263
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the relationship between the polymorphism of the third exon G435T in Ras association domain family 1A (RASSF 1A ) gene and the susceptibility of breast cancer. Methods: The polymorphism of G435T in RASSF 1A gene was determined in 212 female patients with breast cancer, 218 female patients with breast benign disease and 220 female healthy controls by using polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) method, and the correlation of RASSF 1A polymorphism with the susceptibility of breast cancer was evaluated. Results: The frequencies of GT+TT and T allele at G435T site in RASSF 1A gene were significantly higher in patients with breast cancer than those with benign breast disease and healthy controls. Conclusion: The polymorphism of the third exon G435T in RASSF 1A gene may be associated with the susceptibility of breast cancer. RASSF 1A 435T allele can be a potential predictive factor for the risk of breast cancer. Copyright© 2011 by the Editorial Board of Tumor.
