Potential role of nuclear factor of activated T cells in cancer progression
10.3781/j.issn.1000-7431.2011.05.018
- Author:
Man WU
1
Author Information
1. Second Clinical Medicine College
- Publication Type:Journal Article
- Keywords:
Neoplasm;
Neoplasm metastasis;
Nuclear factor of activated T cell;
Transcription factors
- From:
Tumor
2011;31(5):469-473
- CountryChina
- Language:Chinese
-
Abstract:
The nuclear factor of activated T cells (NFAT) - a group of transcription factors ubiquitously expressed in mammalian tissues, plays a critical role in orchestrating the intricate cellular interactions that characterize vertebrate development and morphogenesis. Recently, accumulated evidence points to an emerging role for NFAT transcription factors in cancer progression. Various NFAT isoforms are remarkably functional in tumor cells and multiple compartments in the tumor microenvironment, promoting carcinogenesis and cancer invasion. This review highlights the current knowledge about the role of NFAT in oncobiology, including tumor generation, growth, survival, malignant transformation, invasion, metastasis and angiogenesis. Clarifying the parts played by NFAT in tumor progression will help the development of effective therapeutics that target the NFAT pathway in neoplastic progression and metastasis.
