Classification and regression tree analysis for prediction of recurrence risk in patients with surgically resected lymph node-positive penile cancer
10.3781/j.issn.1000-7431.2011.07.014
- Author:
Yao ZHU
1
Author Information
1. Department of Urology
- Publication Type:Journal Article
- Keywords:
Lymph node excision;
Lymphatic metastasis;
Penile neoplasms;
Prognosis;
Survival rate
- From:
Tumor
2011;31(7):650-652
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To assess the risk of recurrence in patients with surgically resected lymph node-positivepenile cancer by classification and regression tree (CART) analysis. Methods: The medical recordsand follow-up data of sixty patients with surgically resected lymph node-positive penile cancer between 1990 and 2008 were retrospectively analyzed. The node-related prognostic factors were collected,such as the number of positive lymph nodes, unilateral or bilateral lymph node metastasis, pelvic nodal involvement and extranodal involvement. The CART analysis was used to generate a regression tree modelfor identifying recurrence risk of surgically resected lymph node-positive penile cancer, and the tree wasvalidated in this study population. Results: The regression tree model for predicting different recurrencerisk of patients with surgically resected lymph node-positive penile cancer was generated by CART. The positive lymph-node number and the extranodal involvement were both important prognostic factors.The patients with node-positive penile cancer were divided into four groups according to recurrence risk classified by CART. The survival curves showed the distinct difference in recurrence-free survival amongthese four gourps (P <0.05). Conclusion: A regression tree model generated by CART can accurately identify and classify the recurrence risk of patients with surgically resected lymph node-positive penilecancer, and this regression tree may aid individualized decision-making in clinical practice. Copyright© 2011 by TUMOR.
