Expression of CIP2A in non-small cell lung cancer and its clinical significance
10.3781/j.issn.1000-7431.2011.10.012
- Author:
Xiao-Lan XÜ
1
Author Information
1. Department of Geriatric Respiratory Medicine
- Publication Type:Journal Article
- Keywords:
Cancerous inhibitor of protein phosphatase 2A;
Carcinoma, non-small cell lung;
Gene expression;
Immunohistochemistry;
Prognosis
- From:
Tumor
2011;31(10):942-945
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the expression of cancerous inhibitor of protein phosphatase 2A (CIP2A) in non-small cell lung cancer (NSCLC) tissues and its clinical significance. Methods: The expressions of CIP2A protein in NSCLC tissues and their corresponding para-cancerous tissues from 97 cases of NSCLC were detected by immunohistochemistry. The relationship between the expression of CIP2A protein and the clinicopathological features in patients with NSCLC was analyzed. Results: The positive expression rate of CIP2A protein in NSCLC tissues [76.3% (74/97)] was significantly higher than that in the corresponding para-cancerous tissues [5.2% (5/97)] (P <0.01). The positive expression of CIP2A protein was not associated with age, gender, smoking status, histological type,TNM stage, differentiation of tumor, tumor size and lymph node metastasis (P >0.05). The overall survival time of patients with positive expression of CIP2A protein was shorter than that of patients with negative expression of CIP2A protein (P =0.001). The expression of CIP2A protein, TNM stage and the differentiation of tumor were independent prognostic factors of NSCLC (P <0.05). Conclusion: The expression of CIP2A protein is significantly increased in NSCLC tissues, and the positive expression of CIP2A protein is associated with the prognosis of patients with NSCLC. Copyright© 2011 by TUMOR.
