The association between a genetic variant in MKK4 gene promoter and lung cancer risk in Southern Chinese population
10.3781/j.issn.1000-7431.2011.12.006
- Author:
Bin-Fang HUANG
1
Author Information
1. Center of Molecular Epidemiology Research
- Publication Type:Journal Article
- Keywords:
Disease susceptibility;
Lung neoplasms;
Mitogen-activated protein kinase kinases;
Polymorphism, single nucleotide
- From:
Tumor
2011;31(12):1082-1086
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the association between the single nucleotide polymorphism (SNP) of mitogen-activated protein kinase kinase 4 (MKK 4) promoter and the risk of lung cancer development in Southern Chinese population. Methods: A hospital-based case-control study including 800 cases of lung cancer and 900 healthy controls was conducted. TaqMan assay was used to test the SNP of rs3826392 (-1304T>G) in MKK 4 promoter, and the software SAS 9.13 was used to analyze the association of MKK4 polymorphism and the susceptibility of lung cancer. Results: The observed genotype frequency of -1304T>G in MKK4 promoter was appropriate for Hardy-Weinberg equilibrium in the healthy controls (P = 0.149). The distribution of genotypes was significantly different between the cases of lung cancer and the healthy controls (P=0.001). Compared with homozygous genotype (TT), the risk for lung cancer was decreased by 25% in the carriers of heterozygous genotype (TG) [adjusted odd ratio (OR ) = 0.75, 95% confidence interval (CI) = 0.58-0.97)], and the risk for lung cancer in carriers of GG homozygote was decreased by 45% (adjusted OR = 0.55, 95% CI = 0.33-0.94). There was a significantly decreased trend in the risk for lung cancer along with the increased number of mutation-typic G allele (Ptrend<0. 001). Conclusion: These findings demonstrate that -1304T>G genotype in promoter region of MKK4 gene may contribute to the decreased risk of lung cancer. Copyright© 2011 by TUMOR.
