Expressions of serum IL-17 and IL-6 of patients with colorectal carcinoma and their clinical significance
10.3781/j.issn.1000-7431.2012.06.011
- Author:
Wei-Gang HUANG
1
Author Information
1. Department of Clinical Laboratory
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
Cytokines;
Interleukin-17;
Interleukin-6
- From:
Tumor
2012;32(6):458-461
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the expression levels of IL (serum interleukin)-17 and IL-6 of patients with CRC (colorectal cancer), and to investigate the correlation between the levels of serum IL-17 and IL-6 and the development of human CRC. Methods: The expression levels of serum IL-17 and IL-6 of 56 patients with CRC and 30 healthy volunteers (controls) were detected by ELISA. The potential associations between serum IL-17 and IL-6 levels and the clinicopathological characteristics were analyzed. Results: The levels of serum IL-17 and IL-6 of 56 patients with CRC were significantly higher than those of the controls (96.43±21.15 vs 16.88±5.07 ng/L, 139.53±27.84 vs 39.21±7.46 ng/L; P < 0.01). The increased levels of serum IL-17 and IL-6 were not associated with the gender and age of patients with CRC (P > 0.05) but associated with the tumor size, metastasis, Dukes stage and pathological type (P < 0.01). Conclusion: The levels of serum IL-17 and IL-6 increase with the development of CRC, which suggests that IL-17 and IL-6 may directly or indirectly contribute to the development and progression of CRC. © 2012 by Tumor.
