The expressions of B7-H1 and Bcl-2 in human colorectal cancer and their clinical significance
10.3781/j.issn.1000-7431.2012.07.014
- Author:
Xiao-Feng LI
1
Author Information
1. Department of Internal Medicine
- Publication Type:Journal Article
- Keywords:
B7-H1;
Colorectal neoplasms;
Gene, bcl -2;
Immunohistochemistry;
Tumor escape
- From:
Tumor
2012;32(7):555-558
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the expressions of B7-H1 and Bcl-2 proteins in human colorectal cancer, and to explore the association of the expressions of B7-H1 and Bcl-2 with clinicopathological features. Methods: The expressions of B7-H1 and Bcl-2 proteins were detected by immunohistochemistry in colorectal cancer tissues and their corresponding para-cancerous normal tissues from 57 cases of colorectal cancer. The association of the expressions of B7-H1 and Bcl-2 with the clinicopathological features was analyzed. Results: The positive expression rates of B7-H1 and Bcl-2 in colorectal cancer tissues were both higher than those in para-cancerous normal tissues (P <0.05). Both of Bcl-2 and B7-H1 expressions in colorectal cancer tissues were negatively correlated with the degree of differentiation of colorectal cancer (P <0.01). The positive expression rate of B7-H1 was significantly elevated in patients with lymph node metastasis (Dukes' stage C-D) compared to the patients without lymph node metastasis (Dukes' stage A-B) (P <0.05). For the patients with colorectal cancer classified as well or moderately differentiated, the expression rate of Bcl-2 in patients with negative expression of B7-H1 was significantly higher than that in patients with positive expression of B7-H1 (P <0.01). Short-term followup showed that the B7-H1 was expressed in colorectal cancer tissues from the patients died of colorectal cancer. Conclusion: The expression of B7-H1 was correlated with the invasion and metastasis of colorectal cancer as well as the survival. The detection of B7-H1 combined with Bcl-2 may have an important clinical significance in the diagnosis, treatment and prognostic prediction for patients with well/moderately differentiated colorectal cancer. Copyright © 2012 by TUMOR.
