Allogeneic hematopoietic stem cell transplantation followed by sequential infusion of donor-derived cytokine induced killer cells for relapsed/refractory hematologic malignancy: A preliminary study of 9 cases
10.3781/j.issn.1000-7431.2012.07.012
- Author:
Yun LUO
1
Author Information
1. Department of Hematology
- Publication Type:Journal Article
- Keywords:
Cytokineinduced killer cells;
Graft versus host disease;
Hematopoietic stem cell transplantation;
Leukemia
- From:
Tumor
2012;32(7):546-550
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the efficacy and complications of allogeneic peripheral blood stem cell transplantation (Allo-PBSCT) followed by sequential infusion of donor-derived cytokine induced killer (CIK) cells for relapsed/refractory hematologic malignancy. Methods: Nine patients with relapsed/ refractory hematologic malignancy without complete remission received Allo-PBSCT. After hematopoietic reconstitution, the donor-derived peripheral blood mononuclear cells were collected by blood cell separator and cultured into CIK cells in vitro . The CIK cells were infused back into the patients. The therapeutic efficacy, adverse reactions and prognosis were observed. Results: All patients engrafted. Complete remission was also achieved in all patients. After infusion of CIK cells, four patients developed graft-versus -host disease (GVHD) which was relieved by reinforced immunosuppression therapy. One patient died of infection 59 days after Allo-PBSCT, and the other 8 patients survived at a median followup of 9.2 months (2-20 months). Conclusion: Allo-PBSCT followed by sequential infusion of donor-derived CIK cells can salvage the patients with relapsed/refractory hematologic malignancy and it is worthy of further large-scale study. Copyright © 2012 by TUMOR.
