Aiming at tumors and their microenvironments: Targeted strategies of mesenchymal stem cell-mediated genetic therapy
10.3781/j.issn.1000-7431.2013.05.014
- Author:
Ge QU
1
Author Information
1. Department of Thoracic Surgery
- Publication Type:Journal Article
- Keywords:
Genetic therapy;
Mesenchymal stem cells;
Neoplasms;
Tumor microenvironment
- From:
Tumor
2013;33(5):465-472
- CountryChina
- Language:Chinese
-
Abstract:
The early detection of some cancer types combined with the advent of specific drugs has increased median survival of numerous cancer patients. However, many drugs with poor pharmacokinetics rapidly lose activity when delivered systemically and may even not reach the tumors. Based on tropism for tumors, genetic-modified mesenchymal stem cells provide a promising cellular vehicle for drug deliveries. During rapid progression of cancer disease, an activated stromal microenvironment is produced to facilitate tumor development. As a result, it appears a potential chance to modify the cancer therapy in a way, aiming at both the tumor cells and their microenvironments. Copyright © 2013 by TUMOR.
