Advance in the roles of tissue transglutaminase in development, progression, invasion and migration of tumor tissues and the related functional mechanism
10.3781/j.issn.1000-7431.2013.09.014
- Author:
Yue HU
1
Author Information
1. Department of Surgery
- Publication Type:Journal Article
- Keywords:
Neoplasms;
NF-kappa B;
Signal transduction;
Transglutaminase
- From:
Tumor
2013;33(9):831-836
- CountryChina
- Language:Chinese
-
Abstract:
TG2/tTG (tissue transglutaminase) as a multifunctional enzyme is involved in NF-κB (nuclear factor kappa B) and FAK (focal adhesion kinase )/PI3K (phosphatidylinositol3 kinase)/AKT (protein kinase B) pathways to maintain the growth and long-term survival of tumor cells and is also a key regulator of crosstalk between apoptosis and autophagy in the processes of tumorigenesis and progression. TG2 induces adhesion by interacting with extracellular matrix and mediates EMT (epithelial-mesenchymal transition) to promote tumor invasion and metastasis. EGFR (epidermal growth factor receptor) and MMPs (matrix metalloproteinases) regulating the signaling pathway of invasion and metastasis also depend on TG2. This review focuses on the role of TG2 in development, progression, invasion and migration of tumors and the related mechanism, aiming to provide valuable information to develop a new anti-cancer therapeutic strategy. Copyright © 2013 by TUMOR.
