Frequency of myeloid-derived suppressor cells in gastric cancer and its clinical significance
10.3781/j.issn.1000-7431.2013.09.010
- Author:
Yuan GAO
1
Author Information
1. Department of Oncology
- Publication Type:Journal Article
- Keywords:
Antigens;
Myeloid cells;
Stomach neoplasm;
Surface
- From:
Tumor
2013;33(9):809-813
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To detect the proportion of MDSCs (myeloid-derived suppressor cells) in the peripheral blood and dissected tissues of gastric cancer, and to analyze the correlation between the frequency of MDSCs and the clinical and pathological parameters. Methods: The peripheral blood samples before surgical operation and the dissected tissues of gastric cancer from 38 cases were collected. The immunofluorescence and flow cytometry were used to detect the proportions of MDSCs and the expressions of their surface antigens including CD3, CD14, CD19, CD56, CD11b, CD1a and CD18 in the peripheral blood and the cancer tissues. The statistic analysis was used to analyze the correlation between the frequency of MDSCs and the clinical and pathological parameters. Results: MDSCs were found in peripheral blood and cancer tissues with a remarkable high proportion in patients with gastric cancer as compared with that in the healthy volunteers. The myeloid cell antigens were expressed on the surface of MDSCs but the expressions of lineage antigens were absent. The frequency of MDSCs was related to H. pylori (helicobacter pylori) infection and cancer staging. Conclusion: The expansion of MDSCs is involved in development of gastric cancer and this may become a new study focus on gastric cancer intervention. Copyright © 2013 by TUMOR.
