The role of tumor-associated macrophages in remodeling tumor immune microenvironment
10.3781/j.issn.1000-7431.2013.10.014
- Author:
Qiu-Jun GUO
1
Author Information
1. Department of Oncology
- Publication Type:Journal Article
- Keywords:
Immunotherapy, tumor;
Macrophages;
Neoplastic microenvironment;
Neoplastic processes;
Tumor escape
- From:
Tumor
2013;33(10):922-927
- CountryChina
- Language:Chinese
-
Abstract:
Majority of experimental and clinical studies have shown a pro-tumoral function of tumor-associated macrophages (TAMs) which occupy a large part in matrix cells. TAMs promote tumor cell invasion and migration, and their number is related to malignant degree and poor prognosis. Macrophages plasticity makes it possible to change the tumor microenvironment and remodel tumor immune in cancer immunotherapy. Increasing researches have revealed the TAMs' effect on tumor microenvironment and put forward tumor immune treatments aiming at TAMs. Here this review presents the recent research of TAMs in remodeling tumor immune microenvironment and immune targeted therapies, such as the origin of TAMs, the immunosuppression effect of TAMs on tumor microenvironment, tumor extracellular matrix remodeling, and promotion of angiogenesis and lymphangiogenesis Copyright © 2013 by TUMOR.
