Association of single nucleotide polymorphism in untranslated region of EGFR gene with genetic susceptibility of gastric cancer
10.3781/j.issn.1000-7431.2013.04.005
- Author:
Jun-Feng ZHANG
1
Author Information
1. Department of Pathogen and Immunology
- Publication Type:Journal Article
- Keywords:
Epidermal growth factor receptor;
Polymorphism;
Single nucleotide;
Stomach neoplasms;
Untranslated region
- From:
Tumor
2013;33(4):321-326
- CountryChina
- Language:Chinese
-
Abstract:
Objective: This population-based study is aimed to investigate the association of SNP (single nucleotide polymorphism) in untranslated region of EGFR (epidermal growth factor receptor) gene with genetic susceptibility of gastric cancer in Jiangsu province, China. Methods: The peripheral blood samples from 387 patients with gastric cancer and 392 healthy volunteers (as normal controls) were collected. Four SNPs including rs6965469, rs884225, rs884904 and rs763317 in untranslated region of EGFR gene were detected by polymerase chain reaction-ligase detection reaction assay. The associations of these SNPs with the genetic susceptibility of gastric cancer were evaluated. Results: The SNP allele frequencies of rs6965469, rs884225, rs884904 and rs763317 were not significantly different between the patients with gastric cancer and the normal controls (P > 0.05). The frequency of genotype rs6965469 TC was significantly different between the patients with gastric cancer and the normal controls (P < 0.05). The haplotype TGA (rs6965469, rs884225 and rs884904) was associated with a significant increase in risk for gastric cancer [OR (odds ratio) = 3.52, 95% CI (confidence interval): 2.34-5.29] while the haplotype TAG was associated with a significant decrease in risk for gastric cancer (OR = 0.41, 95% CI: 0.26-0.64). Conclusion: The T allele polymorphism in untranslated region of EGFR gene may be associated with the genetic susceptibility of gastric cancer. Combined analysis of SNPs including rs6965469, rs884225 and rs884904 may be useful to predict the risk of gastric cancer in Jiangsu province, China. Copyright © 2013 by TUMOR.
