Protein O-GlcNAcylation and cancer
10.3781/j.issn.1000-7431.2013.11.016
- Author:
Xiao-Bing ZHANG
1
Author Information
1. National Glycoengineering Research Center
- Publication Type:Journal Article
- Keywords:
Glycosylation;
N-acetylglucosamine;
Neoplasm;
Proteins
- From:
Tumor
2013;33(11):1027-1032
- CountryChina
- Language:Chinese
-
Abstract:
O-GlcNAcylation is the addition of a single N-acetylglucosamine (GlcNAc) moiety to the hydroxyl groups of serine or threonine residues of nuclear and cytoplasmic proteins. O-GlcNAc plays an important role in the regulation of many biological processes including, but not limited to, cell cycle progression, transcription, translation, signal transduction, stress response, etc. O-GlcNAc plays significant roles in the progression and etiology of various diseases including diabetes, cardiovascular disease, cancer and Alzheimer's disease. The aberrant O-GlcNAcylation in tumor tissues is closely associated with cell proliferation and metastasis. This review is mainly involved the characteristics of protein O-GlcNAcylation alterations in different types of human cancer and the functions of O-GlcNAcylation in oncogenes and tumor suppressor genes. Copyright © 2013 by TUMOR.
