Comparison of the predictive value of the 6th and the 7th editions of the UICC-AJCC TNM staging systems in prognosis of esophageal cancer after radical resection: Analysis of 400 patients with esophageal cancer
10.3781/j.issn.1000-7431.2013.02.010
- Author:
Jian HE
1
Author Information
1. Department of Oncology
- Publication Type:Journal Article
- Keywords:
Esophageal neoplasms;
Neoplasm staging;
Prognosis;
TNM staging
- From:
Tumor
2013;33(2):164-170
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To compare the predictive value of the 6th and the 7th editions of the UICCAJCC (Union for International Cancer Control-American Joint Committee on Cancer) TNM staging systems in prognosis of esophageal cancer after radical resection. Methods: Four hundred patients receiving radical resection of esophageal cancer between August 2006 and September 2009 were collected. The TNM staging and clinical staging were identified according to the 6th and the 7th editions of the UICCAJCC TNM staging systems. The prognosis-related factors were evaluated using univariate analysis (Kaplan-Meier method) and multivariate analysis (COX proportional hazards model). Results: The threeyear overall survival rates among patients with stages I, II, and III-IV were both significantly different (P < 0.000) according to the 6th and the 7th editions of the UICC-AJCC TNM staging systems. Based on the 7th edition, the three-year overall survival rates among patients with stages IIIA, IIIB, and IIIC were significantly different (P = 0.001); the three-year overall survival rates of the patients with stages N0, N1, N2 and N 3 were 71.8%, 54.4%, 31.6% and 25.0%, respectively, and there existed significant difference in overall survival rate (P < 0.000). The COX proportional hazards model analysis revealed that according to the 6th and the 7th editions of the UICC-AJCC TNM staging systems, the factors of tumor size, differentiation, invasion depth (T staging), and lymph node metastases (N staging) were independent prognostic factors (all P < 0.05) for patients receiving radical resection of esophageal cancer. Conclusion: Both the 6th and the 7th editions of the UICC-AJCC TNM staging systems can be able to reflect the clinical prognosis of patients receiving radical resection of esophageal cancer, and the factors of tumor size, differentiation, invasion depth (T staging) and lymph node metastases (N staging) are the independent predictors of prognosis. Given the 7th edition of the UICC-AJCC TNM staging system for esophageal cancer is more precise than the 6th edition, it can be more effective in the prognostic prediction and the guidance of clinical treatment for patients with esophageal cancer. Copyright © 2013 by TUMOR.
