Progress in understanding of molecular mechanisms of pathogenesis and drug-resistance in ovarian clear cell adenocarcinoma
10.3781/j.issn.1000-7431.2014.55.256
- Author:
Min XIU
1
Author Information
1. Department of Gynecology and Obstetrics, Hospital of Nanchang University
- Publication Type:Journal Article
- Keywords:
Ovarian neoplasms;
Signal transduction;
Targeting therapy;
Tumor markers, biological
- From:
Tumor
2014;34(10):963-968
- CountryChina
- Language:Chinese
-
Abstract:
Ovarian clear cell adenocarcinoma (OCCA) is a special epithelial ovarian cancer with distinct clinical and molecular characteristics from other subtypes. What may contribute to the pathogenesis of OCCA are specific gene mutation in AT-rich interactive domain 1A (ARID1A) and phosphatidyl inositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK 3 CA) as well as aberrant phosphatidyl inositol-3-hydroxy kinas (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR)/hypoxia inducible factor-1α (HIF-1α)/vascular endothelial growth factor (VEGF) signaling pathways. Within the pathways, some specifically expressed molecules, such as hepatocyte nuclear factor-1β (HNF-1β), insulin-like growth factor-binding protein 1 (IGFBP-1) and Napsin A, could be used as potential diagnostic signatures for OCCA. The underlying mechanisms of poor prognosis and resistance to conventional platinum-based chemotherapy are closely related to tumor angiogenesis, low proliferation capacity, DNA repair system and high expression of Stathmin. Developing optimized therapeutic strategies aiming at novel targets, such as mTOR, would provide new insight in the treatment of OCCA.
