Reprogramming of energy metabolism in cancer
10.3781/j.issn.1000-7431.2014.55.244
- Author:
Bai-Hong ZHANG
1
Author Information
1. Department of Oncology, Lanzhou Military Region General Hospital
- Publication Type:Journal Article
- Keywords:
Energy metabolism;
Glutaminolysis;
Glycolysis;
Neoplasms;
Reverse Warburg effect
- From:
Tumor
2014;34(12):1157-1160
- CountryChina
- Language:Chinese
-
Abstract:
Cancers acquire reprogramming of energy metabolism to balance energy production and their biosynthetic needs. The altered metabolism includes aerobic glycolysis, glutaminolysis, reverse Warburg effect and truncated tricarboxylic acid cycle. Cancer cells principally rely on aerobic glycolysis through mitochondrial dysfunction, changes of key metabolic players, hypoxic microenvironment, and genomic changes. Understanding the style and mechanisms of cancer energy metabolism may lead to development of new approaches to reverse metabolic reprogramming.
