The clinical features of breast cancer in young patients
10.3781/j.issn.1000-7431.2014.33.497
- Author:
Xiao-Tong SHI
1
Author Information
1. Department of Head and Neck Surgery, Sir Run Run Shaw Hospital, Zhejiang University
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Molecular subtype;
Overall survival;
TNM stage;
Young
- From:
Tumor
2014;34(12):1138-1143
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore and compare the clinical and pathologic features of breast cancer between the young women (< 40 years old) and the elder women (≥ 40 years old), and to evaluate the overall survival. Methods: There were 1393patients with breast cancer hospitalized in Department of Surgical Oncology, Sir Run Run Shaw Hospital, Medical College, Zhejiang University between August 1996 and April 2011. After exclusion of 15patients whose information of age was missed, 1378patients (194young and 1184elder patients) were included in this retrospective study. breast cancer patients who received treatment in Sir Run Run Shaw Hospital were retrospectively analyzed. The clinicopathological features and the survival were compared between the young and the elder patients. All patients were followed-up, and 218 were lost. The prognostic factors for all patients and young patients were analyzed, respectively. Results: The molecular subtypes, T stage, N stage and the rate of breast-conserving radical surgery were significantly different between the young and the elder patients (P < 0.05), but the positive rates of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor-2 (HER2) and the stages of M and TNM were not significantly different (P > 0.05). The proportion of Luminal B was higher in the young patients than that in the elder patients. The median survial time was not significantly different between the young and the elder patients (58.2 vs 45.8 months, P > 0.05). The univariate analysis revealed that PR-negative and lymph node and distant metastases were associated with lower five-year survival rate in young patients (P < 0.05). The multivariate analysis revealed that lymph node and distant metastases were independent prognostic factors in young patients (P < 0.05). Conclusion: Young patients with breast cancer have more poor prognostic factors than the elders, such as later stages of tumor size and lymph node, more proportion of type Luminal B, and higher rate of breast-conserving radical surgery, but the overall survival between the young and the elder patients had no significant difference.
