Progress in studies of mouse models of colorectal cancer and in vivo tracking techniques
10.3781/j.issn.1000-7431.2015.55.161
- Author:
Yi-Jie CHEN
1
Author Information
1. Laboratory of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-Sen University
- Publication Type:Journal Article
- Keywords:
Animal;
Colorectal neoplasms;
Diagnostic imaging;
Disease models;
In vivo tracking techniques;
Mice
- From:
Tumor
2015;35(1):104-110
- CountryChina
- Language:Chinese
-
Abstract:
Mouse models of colorectal cancer (CRC) are widely used in studies on the pathological mechanism of CRC and its therapeutic strategies, as well as screening the anticancer drugs. In vivo tracking technique, as a prerequisite for the above studies, can maximize the achievement of noninvasive monitoring of the experimental animals, which is of great significance for dynamic study on diseases. There are mainly three categories of mouse models of CRC: induced model, implanted model, and genetically modified model. This article focuses on implanted models and more successful Apc , Smad 3 and K-ras modified models in recent years. In vivo tracking technique also has achieved obvious progress so far, developing some new types of labels and combining multiple modalities of imaging. Here this review discusses some practical examples about the labels combined with different imaging modes in mouse models of CRC, in hope of offering useful references for relevant basic studies.
