The role of intestinal flora in the occurrence and development of colorectal cancer and its mechanism
10.3781/j.issn.1000-7431.2015.55.817
- Author:
Qian LIANG
1
Author Information
1. Department of Gastroenterology, Renji Hospital, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
Inflammation;
Intestinal flora;
Mechanism
- From:
Tumor
2015;35(3):351-355
- CountryChina
- Language:Chinese
-
Abstract:
Colorectal cancer is one of the gastrointestinal tumors whose incidence and mortality are high, and its incidence shows a trend of increasing year by year, doing great harm to human health. Human symbiotic bacteria in gut play a crucial role in nutrition, energy metabolism, immune function and other aspects. Currently, a large number of studies have shown that dysbacteriosis may have an impact on the occurrence of colorectal cancer. Alteration of intestinal flora can promote tumorigenesis through various mechanisms, including causing genetic changes in the gut mucosa epithelial cells, intestinal inflammation, intestinal microenvironment disorders, bacteria toxins, and toxic metabolites. This review discusses the mechanisms of intestinal flora in the occurrence and development of colorectal cancer.
