Clinicopathological characteristics and prognosis of 1006 Uygur and han patients with different molecular subtypes of breast cancer
10.3781/j.issn.1000-7431.2015.33.729
- Author:
Xiu-Juan QIU
1
Author Information
1. Department of Very Important Person, Tumor Hospital Affiliated, Xinjiang Medical University
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Clinical features;
Han nationality;
Molecular subtypes;
Prognosis;
Uygur nationality
- From:
Tumor
2015;35(3):292-300
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the clinicopathological characteristics and prognosis of 1006 Uygur and Han patients with different molecular subtypes of breast cancer. Methods: One thousand and six Uygur and Han patients with breast cancer were divided into different molecular subtypes including Luminal A, Luminal B, human epidermal growth factor receptor-2 (HER-2) enriched and Basal-like, based on estrogen receptor (ER), progesterone receptor (PR), HER-2 and Ki-67. The clinicopathological characteristics and prognosis of Uygur and Han patients with breast cancer of different molecular subtypes were analyzed. Results: The proportions of Uygur patients with Luminal A, Luminal B, HER-2 enriched and Basal-like molecular subtypes were 49.4%, 18.1%, 13.2%, and 19.3%, respectively, as well as 56.5%, 18.1%, 5.9%, and 19.5% in Han patients, respectively; there was a statistically significant difference between Uygur and Han patients (P = 0.002). The rate of distant metastasis of Uygur patients with Luminal A was higher than that of Han patients (P = 0.005). The local recurrence rate of Uygur patients with Luminal B was also higher than that of Han patients (P = 0.012). The six-year disease-free survival rate of Uygur patients with Luminal A was lower than that of Han patients (P < 0.05). The overall six-year survival rate and six-year disease-free survival rate of Uygur patients with Luminal B were lower than those of Han patients (both P < 0.05). The tumor size, TNM stage, histologic grade and molecular subtype were independent prognostic factors affecting overall survival and disease-free survival of breast cancer patients. Conclusion: The proportion of Uygur breast cancer patients with HER-2 enriched subtype is higher than that of Han patients. The distant metastasis rate of Uygur breast cancer patients with Luminal A is high. The local recurrence rate of Uygur breast cancer patients with Luminal B is high, and the prognosis is poor.
