Research progress in voltage-gated sodium channels and tumor
10.3781/j.issn.1000-7431.2016.55.242
- Author:
Yaoyao HU
1
Author Information
1. Department of Oncology, Affiliated Hospital of Zunyi Medical College
- Publication Type:Journal Article
- Keywords:
Nav1.5 voltage-gated sodium channel;
Neoplasm metastasis;
Neoplasms;
Voltage-gated sodium channel beta subunits;
Voltage-gated sodium channels
- From:
Tumor
2016;36(11):1266-1271
- CountryChina
- Language:Chinese
-
Abstract:
Voltage-gated sodium channels (VGSCs) are heteromeric protein complexes containing one core subunit α and one or more auxiliary subunit β. VGSCs are widely expressed in various forms of tumor cells and tissues. Importantly, subunit α can regulate the invasive capacity of tumor cells, and subunit β is related to the adhesion and migration capacities of tumor cells. The function of subunit β in different types of tumor is different. Emerging studies have revealed that VGSCs have certain effects on tumor invasion and metastasis, which indicates that VGSCs may become the target for tumor diagnosis and targeted therapy. Therefore, this paper summarizes the effects of VGSCs on tumor invasion and migration, as well as the research progress in VGSCs used as tumor therapeutic target.
