Biological molecules found to serve as prostate cancer specific promoters during construction of oncolytic adenovirus
10.3781/j.issn.1000-7431.2017.55.708
- Author:
Zhonglin CAI
1
Author Information
1. Department of Urology, Lanzhou University Second Hospital
- Publication Type:Journal Article
- Keywords:
Adenoviruses;
Human;
Prostatic neoplasms;
Transcription initiation site
- From:
Tumor
2017;37(5):534-539
- CountryChina
- Language:Chinese
-
Abstract:
Prostate cancer is a common malignant disease in elder men, and it is the second leading death cause in male cancer patients. The incidence rate of prostate cancer has been increasing year by year, and it is ranked the third in the incidence rate of urologic cancers in China. The oncolytic adenovirus carrying specific promoter has been used as a novel target of antitumor therapy. The adenovirus has specific effects on tumor cells and can express downstream therapeutic genes to inhibit the growth of tumor cells, but it can't influence the normal cells or only has weak influence. At present, oncolytic adenovirus carrying specific promoter which has been used widely in basic and clinical studies has showed unique advantages in great antitumor effect and medication safety. This paper reviews the several biological molecules, which have been found during the construction of oncolytic adenovirus, may potentially become to be prostate cancer-specific promoters.
